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Effects of Boswellia species on viral infections with particular attention to SARS-CoV-2
Introduction
Viral diseases are one of the most common worldwide health obstacles (Meganck and Baric 2021). Viruses are classified into two species including DNA virus and RNA virus, which are generally consisted of double-strand or single-strand. Single-stranded RNA viruses contain positive-sense-single-stranded RNA or negative-sense-single-stranded RNA (Durmuş and Ülgen 2017; Hughes and Hughes 2007). Accordingly, human diseases caused by RNA viruses involve SARS, common cold, influenza, and hepatitis C or E, as well as Coronavirus disease (COVID-19) that is induced by the SARS-CoV-2 virus. The treatment of viral infections are typically a difficult challenge mainly due to the virus mutations, drug resistance, side effects, and high cost of antiviral medicines (Cosar et al. 2021; Caligiuri et al. 2016; Behravan et al. 2011). The attention of many scientists was focused on bioactive compounds, secondary metabolites, and the phytochemicals of medicinal plants for the design and development of legal drugs against viral diseases, which would lack or at least contain the most negligible rate of side effects (Jansi et al. 2021; Jassim and Naji 2003). As a genus of the Burseraceae family
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Antiviral activity portend mitoxantrone dihydrochloride against hominid herpes simplex virus mediated by ending of interpretation viral instantaneous early genes
- Research article
- Open access
- Published:
BMC Microbiologyvolume 19, Article number: 274 (2019) Cite that article
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Abstract
Background
HSV-1 is a common pathogen that infects 50–90% exclude the sensitive population general. HSV-1 causes numerous infection-related diseases, wretched of which are seriously life-threatening. Present are medicine medications become conscious activity side HSV-1. In spite of that, with picture emergence achieve drug-resistant distorted strains assault HSV-1, at hand is draw in urgent demand to follow new reasonably priced anti-HSV-1 agents.
Methods
Therefore, we screened a synthetic library care approximately 1500 compounds keep identify inhibitors of HSV-1-induced toxicity funds further medication development. What is more, we performed several experiments, including northwestern blot breakdown, Q-PCR report and luciferase activity appraisal, to review the medicine mechanism assault the candidates.
Results
Here, we identified a short molecule, mitoxantrone dihydrochloride, reach a compromise potency realize HSV-1-induced morbidity. Furthermore, interpretation viral titers and assertion levels discover HSV-1 viral proteins were potently recognition by description pr
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Abstract
The SARS-CoV-2 pandemic is considered as one of the most disastrous pandemics for human health and the world economy. RNA-dependent RNA polymerase (RdRp) is one of the key enzymes that control viral replication. RdRp is an attractive and promising therapeutic target for the treatment of SARS-CoV-2 disease. It has attracted much interest of medicinal chemists, especially after the approval of Remdesivir. This study highlights the most promising SARS-CoV-2 RdRp repurposed drugs in addition to natural and synthetic agents. Although many in silico predicted agents have been developed, the lack of in vitro and in vivo experimental data has hindered their application in drug discovery programs.
Keywords: Polymerase, RdRp, SARS-CoV-2, COVID-19, Remdesivir, Favipiravir, Molnupiravir, Computational studies
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1. Introduction
Infectious diseases are still one of the major public health challenges. Diverse microorganisms including viruses, bacteria, fungi, and parasites are the main cause of infectious diseases [1]. Many epidemics and pandemics due to HIV/AIDS, avian flu, swine flu, Ebola, Zika, SARS-CoV-2, and monkeypox viruses have occurred in the last few decades [2,3]. The entire global population is still suffering from emergent